肾移植病人术前、术后唾液免疫球蛋白变化及临床意义

THE LEVEL OF sIgA AND LYSOZYME IN SALIVA OF PREOPERATIVE AND POSTOPERATIVE PATIENTS WHO RECEIVED KIDNEY TRANSPLANTATION

目的 :观察肾移植患者口腔病变和唾液sIgA、溶菌酶的关系。方法 :测定 2 8例肾移植患者手术前后唾液sIgA、溶菌酶的含量 ,观察手术前后口腔病变情况 ,并与正常人进行比较。结果 :唾液sIgA含量术前与正常人无差异 ,术后 1周较术前升高 (P <0 .0 5 ) ,术后发生口腔病变者为 34%。主要表现为口干、口腔溃疡、龈苍白及黑毛舌 ,其中口干组唾液sIgA含量较正常组与术前显著升高 (P <0 .0 5 ) ,黑毛舌组较术前与正常组下降。唾液溶菌酶的含量术前较正常人显著升高 (P <0 .0 1) ,术后 1周较术前升高 ,术后 2周下降 ,但较正常人显著升高 (P <0 .0 5 ) ,其含量的变化与sIgA含量变化呈相关关系。结论 :口腔病变是肾移植术后一种免疫性疾病 ,作为机体非特异性免疫因子之一的溶菌酶对肾移植患者具有特殊的意义。

Measurenents of sIgA and Lysozyme level in saliva were taken and situation of oral lesions observed preoperatively and postoperativel in 28 patients who receive kindney transplantation.There are 34% of all the postoperative patients developed oral lesions.The lesions include:dry mouth,oral mucous ulceration,ingival pale and hairy tongue,compared with normal people and preoperative patients,sIgA level of dry mouth group increased significantly ( P <0.05),this level of hairy tongue group decreased.The result suggests that oral lesions are kinds of immuns diseases after kidney trasplantation.Changes of sIgA level is a kind of the body,is of special meaning for the body.Lysozyme as one of nonspecific immunity of the body,is of special meaning for renal patients.