^(60)钴外照射加高剂量率腔内后装治疗鼻咽癌的临床研究

The results of nasopharyngeal carcinoma treated by ^( 60) Co external irradiation plus intracavitary radiotherapy using the high dlose rate afterloading technique

目的 :探讨60 Co外照射加腔内后装放射治疗鼻咽癌的疗效及并发症。方法 :对我院 1985年 7月～ 1993年8月采用60 Co外照射加高剂量率后装腔内放射治疗 5 8例鼻咽癌回顾性分析 ,本组病例随访 5年以上 ,失访按死亡统计。结果 :本组病例 5年局部控制率 84.5 % ( 4 9/5 8) ,5年生存率和无瘤生存率分别为 75 .9% ( 4 4/5 8)和 6 8.9%( 4 0 /5 8)。结论 :外照射加腔内放射治疗可适当减少外照射剂量和放射损伤 。

Objective: The long term results and radiation sequelae of nasopharyngeal carcinoma treated by 60 Co external irradiation plus the high dose rate afterloading intracavity radiation (AIR) were analysed.Methods: From July 1985 to August 1988,58 patients with nasopharyngeal carcinoma were treated by 60 Co external irradiation plus the high dose rate AIR.The AIR was given as a routine boost or for residual disease.The external irradiation dose varied from 55 to 70 Gy,whereas AIR dose ranged from 10 to 45 Gy.Results: All patients were followed up for more than 5 years.The 5 year local control rate was 84.5%.The 5 year actuarial survival and disease free rates were 75.9%,65.5% respectively.Conclusion: We think that AIR for nasopharyngeal carcinoma is indicated for boosting the dose to the nasopharyngeal cavity with appropriated reduction in external irradiation dose,and for residual disease after primary external radiotherapy.