氯沙坦对高血压左室肥厚和左室舒张功能的影响

Effects of Losartan on Left Ventricular Hypertrophy and Attenuated Diastolic Function in Hypertension

目的 :研究氯沙坦对早期高血压心室肥厚和左室舒张功能的影响。方法 :血浆肾素活性、血管紧张素Ⅱ、醛固酮及血清Ⅲ型前胶原的含量在治疗前后被测定。左心室肥厚指标及心肌舒张功能用彩色多谱心动仪测定。结果 :治疗 8周后血浆醛固酮及血清Ⅲ型前胶原的含量降低 ,快速充盈峰速 (E)与心房收缩峰速 (A)之比升高 ,而室间隔厚度 (IVS)、左室后壁厚度 (PWT)及左室心肌重量指数 (LVMI)治疗前后未有明显变化。结论 :氯沙坦在有效降低血压的同时 ,具有明显的降低血清前胶原和改善左心舒张功能的作用。

Objective:To investigate the effect of losartan on left ventricular hypertrophy and attenuated diastolic function in hypertension. Methods:Thirty two essential hypertension patients (WHO class Ⅱ) were treated with losartan for eight weeks.Plasma renninactivity, angiotensin Ⅱ (AngⅡ), aldosterone and procollagen Ⅲ were determined. The left ventricular mass and ventricular function were monitored by color Doppler cardiography. Results:Levels of aldosterone and PCⅢ decreased significantly. The ratio of peak velocity at rapid filling (E) and atrial contraction (A) increased. The thickness of interventricular septum (IVS)and posterior wall, left ventricular mass index were not altered. Conclusion:Blood pressure, PCⅢ and the diastolic function were improved after the treatment by losartan.