Ia期非小细胞肺癌的肿块大小与预后的探讨

Study of Ⅰa Nsclc betweem Tumor Size and Prognosis

目的 :探讨病变直径在 2cm内的Ia期非小细胞肺癌 (NSCLC)的预后是否比病变直径超过 2cm的预后好。方法 :回顾了32例术前诊断为T1 +N0 M0 的病例。以肿瘤直径 2cm为准分为两组。参照各种因素 ,比较了两组的预后和探讨了Ia期NSCLC的预后因素。结果 :两组间的生存率没有明显差异。对Ia期NSCLC的生存期有统计意义的因素是血清CEA和淋巴结转移情况。CEA异常的病例病理学上都诊断为Ⅱ期或Ⅱ期以上。结论 :以 2cm为标准 ,根据肿瘤直径大小对Ia期NSCLC进一步分类临床意义不大 ,而术前血清CEA是最重要的预后因素。

Objective:We aimed to determine whether the prognosis of non small cell lung cancer(NSCLC), with lesions 2 cm or less in diameter,was better than that of stage Ia lung cancer having a diameter of more than 2 cm. Methods:we reviewed 32 cases of NSCLC which were properatively diagnosed as T 1N 0M 0. The tumors were classified into 2 groups on the basis of a tumor diameter set at 2 cm . After comparision of background factors, We compared the prognosis of the groups and determined the prognostic factors in stage Ia NSCLC. Results: No differences were observed in the survival rate between the 2 groups. Statistically significant factors for the survival period in stage Ia NSCLC were serum carcinoembryonic antigen (CEA) and lymphnode metastasis. Those cases where CEA was abnormal were all in stage Ⅱ or even more advanced stage. Conclusion:It is not justifiable to sub classify stag Ia NSCLC on the basis of a tumor diameter of 2 cm. The present study revealed that the most important preoperative prognostic facto was serum CEA.