肿瘤与表皮生长因子的关系研究

Study on Salvia EGF of Tumor Patients and Serum EGF of C57BL/6 Mice Bearing Lewis Lung Cancer

目的 :通过观察肿瘤病人唾液和荷瘤动物血清中表皮生长因子 (EGF)的含量 ,研究肿瘤与EGF的关系。方法 :采用1 2 5I放射免疫分析法 (RIA)。结果 :1 52例肿瘤病人唾液中EGF含量为 ( 4 .0 70± 1 .0 ) μg L ,明显高于正常人的 ( 3.0 71± 1 .7) μg L (P <0 .0 1 ) ;荷瘤小鼠血清中EGF含量为 ( 0 .2 8± 0 .0 9) μg L ,明显高于正常小鼠的 ( 0 .1 8± 0 .1 1 ) μg L (P <0 .0 5)。 结论 :EGF含量升高与肿瘤生长密切相关。

Objective: The salvia EGF of tumor patients and the serum EGF of C57BL/6 mice bearing Lewis lung cancer were studied. Methods: Salvia EGF and serum EGF content were detected by 125 I EGF radioimmunoassay (RIA). Results: Salvia EGF content of 152 tumor patients was ( 4.070 ±1.0) μg/L, evidently higher than that of normal human being [(3.071±1.7) μg/L],serum EGF content of mice bearing Lewis lung cancer was (0.28±0.09) μg/L, higher than that of normal mice [(0.18±0.11) μg/L,( P <0.05)].Conclusion: The study shows that the growth of tumor may be closely related to EGF.