妊娠期肝内胆汁淤积症不同孕周及不同分娩方式对胎儿的影响

The Effects of Intrahepatic Cholestasis of Pregnancy during the Different Week of Gestation on the Perinatal

目的 :了解妊娠期肝内胆汁淤积症 (ICP)在不同孕周对围产儿的影响 ,探讨最佳分娩时机及最佳分娩方式。方法 :对ICP孕妇行肝功能和血生化测定 ,严密观察产程进展 ,产后随访围产儿预后。结果 :36～ 38周ICP围产儿羊水污染及新生儿窒息 (Apgar评分 <4分 )率均明显低于孕周小于 36周和大于 38周者 (均P <0 .0 5) ;ICP患者随机剖宫产围产儿预后明显好于阴道分娩者和指征剖宫产者 (均P <0 .0 5>;指征剖宫围产儿预后与阴道分娩者无显著性差异 (P >0 .0 5)。结论 :36～ 38孕周是ICP患者终止妊娠的最佳时机 ;选择剖宫产终止妊娠 ,对围产儿预后最佳。

Objective:To study the effects of intrahepatic cholestasis of pregnancy(ICP)during the different week of gestation on the perinatal.To probe the best opportunity and way of labor.Method:We tested liver function of trimester were for over 32 weeks and observed their birth process.The perinatal period was followed up after labor.Results:The rates of amniotic fluid pollution and natal stifle (A P <4)of the ICP perinatal during the 36～38 week's gestation were significantly lower than those of ICP perinatal less than 36 weeks or over 3～8 weeks ( P <0.05). The prognoses of perinatal whose mother adopted the random cesarean section were significantly better than those whose mother delivered through vagina or adopted cesarean section according to the indication( P <0.05).There was no significant difference for the prognoses of perinatal between the delivery through vagina and cesarean section according to the indication.Conclusions:It's the best opportunity to end the pregnancy during 36～38week's period for ICP period.It will benefit the perinatal if the gravida chooses cesarean section to end the pregnancy.