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脑白质选择性缺血损伤的机制 被引量：3

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摘要 大脑白质具有选择性缺血易损性，但其机制至今仍未完全明了。脑白质区的血管解剖与血脑屏障因素是其缺血损伤的基础，炎症性胶质细胞反应具有促进作用，神经元轴突、少突胶质细胞及其髓鞘损伤是其结局．此外，血压与脑白质缺血损伤的发生和发展也密切相关．
作者 汪长胜 霍正禄 杨瑞和
机构地区 解放军第 第二军医大学长海医院急诊科
出处 《国外医学（脑血管疾病分册）》 2001年第6期353-356,共4页 Foreign Medical Sciences Cerebrovascular Diseases
关键词 脑缺血 白质 胶质细胞 炎症反应 病理
分类号 R743 [医药卫生—神经病学与精神病学]
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参考文献20

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  • 2Leys D, Englund E, Del-Ser T, et al. White matter changes in stroke patients. Relationship with stroke subtype and outcome. Eur Neurol,1999, 42(2): 67-75.
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同被引文献33

  • 1包维民,郭永章,李立,唐映梅,杨晋辉.冷/热缺血再灌注损伤对大鼠肝脏细胞能量状态、凋亡和胀亡的影响[J].中华实验外科杂志,2005,22(3):302-304. 被引量：10
  • 2顾天爵.生物化学5版[M].北京:人民卫生出版社,1998.1-349.
  • 3王新德 魏岗之.神经病学神经系统脱髓鞘性疾病[M].北京:人民军医出版社,2003.1-238.
  • 4Baumann N, Phan-Dinh D. Biology of oligodendrocyte and myelin in the mammalian central nervous system. Physiol Rev 2001;81(2):871-927
  • 5Mandai K, Matsumoto M, Kitagawa K, et al. Ischemic damage and subsequent proliferation of oligodendrocytes in focal cerebral ischemia. Neuroscience 1997;77(3):.849-61
  • 6Morin-Richaud C, Feldblum S, Privat A. Astrocytes and oligodendrocytes reactions after a total section of the rat spinal cord. Brain Res 1998;783(1):85-101
  • 7Sponne IE, Gaire D, Stabler SP, et al. Inhibition of vitamin B12 metabolism by OH-cobalamin c-lactam in rat oligodendrocytes in culture: a model for studying neuropathy due to vitamin B12 deficiency. Neurosci Lett 2000; 288(3) :191-4
  • 8Pantoni L, Garcia JH. Pathogenesis of leukoaraiosis: a review. Stroke 1997 ;28(3):652-9
  • 9Wallin A, Sjogren M, Edman A, et al. Symptoms, vascular risk factors and blood-brain barrier function in relation to CT white-matter changes in dementia. Eur Neurol 2000,44(4):229-35
  • 10Tzourio C, Levy C,Dufouil C, et al. Low cerebral blood flow velocity and risk of white matter hyperintensities. Ann Neurol 2001;49(3):411-4

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国外医学（脑血管疾病分册）
2001年 第6期

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