TACE联合PEI治疗原发性肝癌血液循环性肝癌细胞的变化及意义

The changes and significance of circulating hepatocellular carcinoma(HCC) cells using combination TACE and PEI treatments of HCC

目的 :探讨联合经肝动脉化疗栓塞术 (TACE)及B超引导下肿瘤局部无水酒精注射术 (PEI) ,治疗原发性肝癌周围静脉血液循环性肝癌细胞的变化及其意义。方法 :应用巢式RT PCR检测 12例原发性肝癌患者血液循环性肝癌细胞 ,并经TACE及PEI联合治疗 ,观察其血液循环性肝癌细胞的变化。结果 :血液循环性肝癌细胞表达阳性的 5例原发性肝癌患者 (41.6 7% ) ,经TACE及PEI联合治疗后 ,其血液循环性肝癌细胞均转为阴性 (10 0 % ,P <0 .0 1)。结论 :联合TACE及PEI治疗原发性肝癌可有效地杀灭血液中播散的循环性肝癌细胞 ,可预防肝癌的复发和转移。

Objective:To study effects and significance of combination transateral chemo embolization(TACE) and percutaneous ethanol injection(PEI) in the treatment of hepatocellular carcinoma(HCC).Methods:We detected 12 blood samples from the HCC patients by nested RT PCR to find out AFPmRNA before and after treatments.Results:All 5 patients with AFPmRNA positive before treatments(41.67%) were indicated with AFPmRNA negative after treatments.Conclusion:Combination TACE and PEI in the treatments of HCC may prevent distant metastasis of HCC or HCC recurrence.