大肠癌肝转移介入治疗的临床研究

A clinical study of interventional therapy for liver metastases from colorectal carcinoma

目的 评价介入治疗大肠癌肝转移的疗效和影响疗效的因素。方法 对 80例大肠癌肝转移介入治疗后得到随访患者的生存期和预后因素进行统计分析。结果 0 .5、1、2和 3年累积生存率分别为 10 0 %、75 .8%、31.5 %和 10 .8%。单因素分析显示 ,有意义的预后因素是患者年龄、肿瘤占据率(与全肝比值 )、病灶血供丰富与否和碘油沉积情况、原发病灶是否切除以及治疗后病灶大小差别 ;多因素分析为病灶血供情况和治疗后病灶大小差别。结论 经肝动脉介入治疗是大肠癌肝转移的有效治疗方法。

Objective To evaluate the efficacy and prognostic factors in patients with liver metastases from colorectal carcinoma treated by interventional therapy.Methods Follow up information of 80 patients with liver metastases from colorectal carcinoma were analyzed. The survival time and parameters were likely to affect the prognosis revealed by statistical methods. Results It was shown that the over all 0.5,1,2,3year survival rates were 100%,75.8%, 31.5% and 10.8% respectively. Univariate analysis showed that the age, the volume ratio of the tumors/liver, abundance of the tumor vessels, the retention of the lipiodol, resection of the original lesion and the difference of the tumor sizes between pre therapy and post therapy were the significant prognostic factors. Multivariate analysis showed that abundance of the tumor vessels and the difference of the tumor sizes between pre therapy and post therapy were the most significant factors. Conclusions The hepatic arterial infusion chemotherapy and embolization are effective to patients with liver metastases from colorectal carcinoma proportionately to the tumor vascular abundance and primary lesion resection.