肺结核患者血清肿瘤坏死因子-α、内皮素-1的含量及临床分析

Clinical analysis and content of TNF-α and ET-1 in serum for pulmonary tuberculosis patients

目的：研究血清肿瘤坏死因子－α（ＴＮＦ－α）、内皮素－１（ＥＴ－１）在肺结核发病中的作用和临床意义。方法：采用放射免疫法检测４５例肺结核患者和２０例正常人血清中肿瘤坏死因子－α、内皮素－１的含量。结果：①所有进展期患者两项都增高。②治疗前离于治疗后。③Ⅱ，Ⅳ型肺结核 ＴＮＦ－α高于其它类型。④ＥＴ－１再复治组合并肺心病呼吸表蝎、肺纤维化、肺部感染高于单纯肺结核。结论：ＴＮＦ－α，ＥＴ－１与肺结核发生、发展和转归有关。

Objective: It is to study clinical value of TNF-α and ET-1 in pulmonary tuberculosis(TB). Methods: Forty-five cases pulmonary TB patients and 20 cases normal people were detected by radio immuno technique. Results: ① Serum of TNF-α and ET-1 were higher in all progressive stage pulmonary TB patients. ②Before treatment the serum levels were higher than that after treament. ③In the Ⅱ /Ⅳ type pulmonary TB serum levels of TNF-α was higher than others. ④The serum levels ET-1 was higher in repeatedly treat group with cor pilmonale, pulmonale fibrosis, respiratory failure and pulmonary infection than patients with merely pulmonary TB. Conclusion: TNF-α and ET-1 have something to do with the occurrence, development and anticipate of pulmonary TB.