TH1/TH2在慢性乙型肝炎发病机制中的作用

Effect of Th1/Th2 on pathogenesis with chronic hepatitis B

目的 :研究Th1/Th2变化在慢性乙型肝炎发病机制中的作用。方法采用双抗体酶联分析法检测了 2 0例正常人 ,30例慢性乙型肝炎患者血清中的IFN γ、IL 2、IL 4和IL 6的水平。结果 :慢性乙型肝炎组Th2类细胞因子 (IL 4、IL 6 )水平明显高于正常对照组 (P <0 .0 5 ) ,Th1类细胞因子IL 2水平较正常组也增高 (P <0 .0 5 ) ,IFN γ水平轻度增加 ,但无统计学差异 (P >0 .0 5 )。结论 :Th2类细胞因子水平增高以及由此引起的Th1/Th2比值下降可能与慢性乙型肝炎的病程持续有关。

Objective: To study the effects of between Th1 and Th2 cytokines in chronic HBV infection.Methods: Serum levels of Th1 cytokines (IFN-γ and IL-2)and Th2 cytokines (IL-4 and IL-6)were measured by enzyme-linked immunosorbent assay in this study,20 healthy subjects as normal controls and 30 chronic HBV infected patients were observed.Results:Th2 cytokines (IL-4 and IL-6)were significantly increased in chronic HBV infected patients compared with normal controls(P<0.05).Similarly,the level of Th1 cytokine (IL-2)was also elevated in individuals with chronic HBV infection compared with normal controls(P<0.05).However,Th1 cytokine (IFN-γ)level was slightly increased,but no difference was found between chronic HBV infection and normal controls(P>0.05).Conclusion: The levels of Th2 cytokines are higher than Th1 cytokines in HBV infection.The study indicates that there exists a low ratio of Th1/Th2 in chronic HBV infected patients and an enhanced Th2 responses are present during HBV infection,which may partly be responsible for the persistesce of HBV infection.