微量元素Se,Mn,Fe和Mo与崇明岛肝癌高发的关系(英文)

STUDY ON THE RELATION OF Se, Mn, Fe AND Mo TO LIVER CANCER MORTALITY

本工作利用崇明岛作为一个肝癌高发区以及岛内东西部之间肝癌发病率的差异来研究微量元素和肝癌发病之间的关系。通过比较研究肝癌高低发区健康人群头发中铁、铅、锶、锰、钙、钛、钼、锌、铜和硒等十个元素含量和100例病例对照研究,我们发现崇明岛正常人群头发中硒的含量低于我国其它地区报导的硒值(除了克山病区外)。提示崇明岛可能存在着硒的缺乏,而硒的缺乏可能是崇明岛肝癌高发的危险因素之一。人发中的Mn、Fe和Mo的含量显示了明显的地区差异并和肝癌发病率呈显著负相关。病例对照研究表明肝癌病人发中Mn和Fe低于正常对照组。

This work was to make use of the Chongming island as a high prevalence area of liver cancer and its uneven geographical distribution to study the relation between trace elements and high liver cancer incidence. Fe, Pb, Sr, Mn, Ti, Mo, Zn, Cu and Se contents in scalp hair of healthy adults from the areas with lower and higher cancer mortality respectively were determined and 100 palirs of case-control investigation was made. The selenium hair content of healthy adult on the island is in the range of 0.222 - 0.378 ppm. The average is about 0.309 ppm. This is lower compared with other places in China, wnich might indicate a selenium deficiency, one of the risk factors responsible for liver, cancer. The Mn, Fe and Mo hair content showed a geographical differences significantly and had a negative correlation with liver cancer Mortality. Results of the case-control study indicate Mn and Fc hair content from liver cancer patients were significantly lower than normals.