固相合成促性腺激素释放激素GhRH及其类似物

Solid Phase Synthesis of Gonadotropic HormoneRelease Hormone(GhRH) and Analogs

采用Merrifield多肽固相合成法 ,合成了促性腺激素释放激素GhRH ,即PGlu·His·Try·Ser·Tyr·Gly·Leu·Arg·Pro·Gly·NH2 以及类似物 [D -Ala6][去Gly·NH102 ]GhRH乙基酰胺 ,即PGlu·His·Try·Ser·Tyr·D -Ala·Leu·Arg·Pro·NH C2 H5和 [Arg2 ]GhRH ,即PGlu·Arg·Try·Ser·Tyr·Gly·Leu·Arg·Pro·Gly·NH2 。

Based on solid phase polypeptide synthesis,GhRH were synthesised,that is PGlu-His-Try-Ser-Tyr-Gly-Leu-Arg-Pro-Gly·NH 2,analogs [des-Gly·NH 10 2]GhRH ethyl-acidamide reach PGlu-His-Try-Ser-Tyr-D-Ala-Leu-Arg-Pro·NH-C 2H 5 and GhRH raech PGlu-Arg-Try-Ser-Tyr-Gly-Leu-Arg-Pro-Gly·NH 2.