Melkersson-Rosenthal综合征(附3例报告)

Melkersson-Rosenthal Syndrome(3 Cases Report)

目的 探讨 Melkersson-Rosenthal综合征 ( MRS)的临床特点及发病机制。方法 分析本院近 1 0年来收治的 3例完全型 MRS患者临床及随访资料。结果 3例患者临床资料符合完全性 MRS的诊断 ,即间歇性面瘫、再发性唇面肿及皱襞舌 ,其中 1例有家族性皱襞舌。结论 MRS发病机制可能与免疫功能异常所致组织炎性肉芽肿有关 ,激素治疗有效。

Objective To investigate the clinical manifestation of Melkersson Rosenthal syndrome(MRS).Methods We report three definite MRS cases in our hospital from 1991 to 2000 and discuss its causes, pathogenesis and clinical features refering to recent literature.Results MRS is a rare disorder of unknown etiology, with the clinical manifestation of recurrent lip and/or face swelling,fissured tongue,and intermittent peripheral facial palsy.Conclusions MRS can be effectively treated with glucocorticosteroids. This syndrome is hard to be correctly diagnosed in the early stage.It was concluded that immune dysfunction might participate in the pathogenesis of this syndrome, and pathologically was a granuloma.