上皮钙粘附素和表皮生长因子受体在非小细胞肺癌中的表达及相关性研究

THE EXPRESSION OF E-CADHERIN AND EPIDERMAL GROWTH FACT OR RECEPTOR IN NON-SMALL-CELL LUNG CANCER AND ITS CLINICAL SIGNIFICANCE

探讨肺癌细胞上皮钙粘附素和表皮生长因子受体的表达、两者之间的相关性及其与病理生物行为的关系。方法 :常用免疫组化法回顾性研究了 5 8例非小细胞肺癌标本E -cd和EGFR的表达 ,并分析其表达与病理类型、分化程度和淋巴结转移的关系。结果 :5 8例肺癌标本中E -cd强阳性表达 18例 (32 .76 % ) ;EGFR强阳性表达 2 7例 (46 .5 5 % ) ,弱阳性表达 19例 (32 .76 % ) ;E -cd和EGFR的表达与病理类型均无关 ;E -cd的表达与分化程度有关 ;E -cd和EGFR的表达均与有无淋巴结转移密切相关 ;E -cd与EGFR的表达呈负相关关系 (r=- 0 .35 5 5 ,P =0 .0 0 6 2 )。结论 :E -cd与EGFR的表达与非小细胞肺癌的生长分化、淋巴转移等恶性行为密切相关 ,EGFR的高表达可能是E -cd表达水平降低有关。

Objective:To investigate the expressionl of E- Cad herin and epidermal growth factor receptor in non-small-cell lung cancer and its clinical significance.Methods:The expression of E-Cadherin and epidermal growth factor receptor in 58 cases of non-small-cell lung cancer tissue sections was detecte d by immunohistochemistry. Correlations were investigated between E-cd and EGFR immunostaining in primary tumors and histological grade, lymph node stage.Results:18 of 58 cases showed strong E-cd immunostaining and 27 of 58 cases showed strong EGFR immunostaining.E-cd expressionl showed significan t correlation with grades of differentiation. There were significant correlations between E-cd and EGFR expression and lymph node metastasis.Conclusions:E-cd and EGFR expression in surgically treated NSCLC is clearly associated with lymph node metastasis and histological grade.