中脑导水管周围灰质微量注射N-硝基左旋精氨酸和硝普钠对大鼠血压的影响

Influence of blood pressure after microinjection N-Nitro-L-Arginine and sodium nitroprussid into periaqueductral gray of midbrain in rats

目的 研究中脑导水管周围灰质 (PAG)内NO对血压的作用。方法 采用PAG微量注射N 硝基左旋精氨酸和硝普钠 ,观察大鼠血压的变化。结果 PAG微量注射N 硝荃左旋精氨酸 (L NNA)后 ,平均动脉压 (MAP)显著升高 ,此效应可被预先注射L Arg逆转。PAG微量注射硝普钠 (SNP)后 ,MAP显著降低 ,此效应可被预先注射荷包丹碱 (Bic)递转。结论 PAG内L Arg NO通路对动物血压有紧张性抑制作用 ,可能是通过GABA受体介导。

Objective To study the effect of nitric oxide(NO)on blood pressure in midbrain periaqueductal gray(PAG)of rats.Methods The changes of blood pressure in rats were observed after microinjction of N Nnitro L Anginine(L NNA)vs,sodium nitroprussid(SNP)into PAG.Results Following microinjection of L NNA into PAG,mean arterial pressure (MAP) increased significantly.The effects could be reversed by prior intravenous injection of L arginine(L Arg).In response to microinjection of SNP into PAG,MAP decreased significantly.The effects could be attenuoted by preinjection of bicuceline(Bic).Conclusions L Arg No pathway may tonically inhibit blood pressure,which(may) be mediated through γ aminobutyric acid(GABA)receptor.