C-erbB-2及nm23在乳腺癌中的表达及其临床意义

Expression of C-erbB-2 and nm23 Protein in Breast Carcinoma and Their Clinical Significance

目的 研究C erbB 2和nm2 3在乳腺癌中的表达及临床预后价值。方法 应用免疫组化S P法检测 6 5例临床随访资料完整的乳腺癌患者标本中 ,C erbB 2和nm2 3的表达情况 ,用Cox回归分析其预后意义。结果 C erbB 2及nm2 3阳性表达率分别为 4 0 %和 5 5 .4 %。C erbB 2表达与腋淋巴结状态呈正相关 ,与生存率呈负相关 ,而nm2 3表达则相反。多因素Cox回归分析显示 ,腋淋巴结状态 ,C erbB 2及nm2 3过度表达等 3项指标反映乳腺癌预后情况 ,危险度分别为3.10 4 6 ,2 .6 5 82 ,0 .370 4。结论 C erbB 2及nm2 3是仅次于乳腺癌腋淋巴结状态的独立的预后指标 ,联合检测可提高其预后价值。

Objective To study the expression and clinical significance of C\|erbB\|2 and nm23 protein in breast carcinoma.Methods Tissue samples from 65 cases of breast carcinoma with full follow\|up data were examined by immunohistochemical S\|P methods and overexpression of their C\|erbB\|2 and nm23 protein was evaluated. Their prognostic value was analyzed by cox regression mode.Results Of the 65 breast carcinoma specimens, 40% were C\|erbB\|2 positive and 55.4% were nm23 positive. Overexpression of C\|erbB\|2 was positively correlated to lymph node involvement and negatively correlated to survival. Overexpression of nm23 was reverse.In both monovariate Kaplan\|Meier plot and multivariate Cox regression analysis, involvement of axillary lymph node, overexpression of C\|erbB\|2 and nm23 were three important prognostic factors of breast carcinoma.The hazard ratios of axillary lymph node involvemnt, overexpression of C\|erbB\|2 and nm23 were 3.1046, 2.6582,0.3704, respectively.Conclusion Expression of C\|erbB\|2 and nm23 could be two useful prognostic indicators only inferior to axillary lymph node of breast carcinoma.