小剂量米索前列醇后穹窿给药用于足月妊娠引产的安全性探讨

Safety of small-dose misoprostol in the posterior vaginal fornix on induction of labor in term pregnancy

目的 :探讨米索前列醇 ( misoprostol,米索 )用于足月妊娠引产的安全性。方法 :选取同期引产的足月妊娠孕妇 94例 ,随机分成米索组 4 6例 ,蓖麻油组 4 8例 ,米索组给予米索 2 5 ︼g,置阴道后穹窿 ,间隔 4 h重复给药 ,共 3次 ;蓖麻油组给予蓖麻油 5 0 m l煎蛋服用 ,分别观察产程进展情况。结果 :米索组出现异常宫缩 (包括不协调宫缩及宫缩过频 ) 18例 ,占 3 9.1% ,蓖麻油组出现宫缩过强而急产 2例 ,占 4 .2 % ;米索组宫缩应激试验 ( + ) 10例 ,占 2 1.7% ,蓖麻油组 3例 ,占 6.3 % ,差异有统计学意义 ( P<0 .0 5 ) ,2组羊水混浊发生率分别为 2 8.3 %和 10 .4 % ,差异有统计学意义 ( P<0 .0 5 )。剖宫产原因中 ,胎儿宫内窘迫为主要手术指征 ,米索组 11例 ,占剖宫产 84 .6% ,蓖麻油组 4例 ,占剖宫产 5 7.1%。结论 :米索用于足月妊娠引产 。

AIM: To explore the safety on misoprostol for labor induction in term pregnacy. ME THODS: Ninety four pregnant women at the same period were selected in our groups. They were randomly divided into misoprostol group (46 cases) and castor oil group (48 cases). 25 μg misoprostol was placed in the posterior vaginal fornix every 4 h, totally 3 times; 50 ml castor oil fried eggs were eaten in castor oil group to observe the progress of labor. RESULTS: Abnormal uterine contraction (irregular and frequent) was found in 18 cases (39 1%) in misoprostol group. Hypertonic uterine contraction and fast labor were found in 2 cases (4 2%) in castor oil group. The incidence of CST (+) was 21 7% (10 cases) and 6 3% (3 cases), respectively. There was significant difference ( P <0 05). The incidence of the amnatic turbidity was 28 3% and 10 4%, respectively. There was significant difference ( P <0 05). The fetal distress was the major cause of cesarean section. Each of them accounts for 84 6% (11 cases) and 57 1% (4 cases). CONCLUSION: Misoprostol has the potential unsafe factors on pregnancy and fetus for labor induction in term pregnancy.