期刊文献+

胰岛素、糖和脂肪代谢异常与高血压病关系的探讨

Relation between Hypertension and Metabolic Abnormality of Insulin, Glucose and Fat
下载PDF
导出
摘要 目的 :研究高血压病与胰岛素、糖和脂肪代谢以及血清阳离子的关系 ,为有效防治高血压及其并发症提供依据。方法 :随机选择高血压病患者 10 2例 ,按高血压病家族史、性别、年龄配对选择 10 2例正常血压者作为对照 ,比较胰岛素、糖、脂肪及血清阳离子在两组的分布特点。结果 :①高血压病组胰岛素、血糖、低密度脂蛋白胆固醇 (LDL C)、胆固醇 (Ch)水平高于正常血压组 ,高密度脂蛋白胆固醇 (HDL C)低于正常血压组 ,但无显著性差异 ;高血压病组的甘油三酯 (TG)及血清Na+ 、Ca2 + 浓度均高于正常血压组 ,血清钾则低于正常血压组 ,且有统计学意义 ;②简单相关分析显示 :胰岛素水平与LDL C、Ch、TG呈正相关 ,与HDL C呈负相关 ;血糖水平与Ch、TG呈正相关 ;SBP和DBP与BMI和TG呈正相关 ;BMI与TG呈正相关 ,均有统计学差异 ;③多元逐步回归分析表明DBP和MBP与胰岛素及血清Na+ 、Ca2 + 呈正相关 ,与血清K+ 呈负相关。结论 :提示高血压病患者有胰岛素水平增高和胰岛素抵抗的趋势 ,胰岛素、糖和脂肪代谢间存在密切相关关系 。
出处 《广州医药》 2001年第6期17-19,共3页 Guangzhou Medical Journal
  • 相关文献

参考文献7

  • 1Ferrannini E, Haffner S A, Stem M P. Essential hypertension:aninsulin- resistant state. J Cardiovasc Pharmacol, 1990, 15(Suppl1S): S18.
  • 2Kuriyama S, Tokudome G, Tomonari H. Differential regulation of cation transport of vascular smooth muscle cells in a high glucose concentration milieu. Diabetes Res Clin Pract, 1994,24(2) :77.
  • 3King G L, Goodman A D, Buzney S, et al. Receptors and growthpromoting effects of insulin and insulin like growth factors on cells from bovine retinal capillaries and aorta. J Clin Invest,1985, 75: 1028.
  • 4Landin K, Tengbom L, Smith U. Elevated fibrinogen and plasminogen activator inhibitor (PAL-1) in hypertension are related to metabolic risk factors for cardiovascular disease. J Intern Med,1990, 227: 273.
  • 5Draznin N, Sussman K, Kao M, et al. The existence of an optional range of cytosolic free calcium for insulin-stimulated glucose transport in rat adipocytes. J Biol Chem, 1987, 262: 1438.
  • 6Zicha J, Dobesova Z, Kunes J. Plasma triglycerides and red cellion transport alteration in genetically hypertensive rats. Hypertension, 1997, 30 (sPt2): 636.
  • 7Asano M, Nomura Y, Ito K, et al. Increased function of voltagedependent Ca2+ channels and Ca2 + activated K + channels in resting state of temporal arteries from spontaneously hypertenive rats at prehypertensive stage. J Pharmacol Exp Ther, 1995, 275(2): 775.

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部