p53、p21^(WAF1)及p16在胃癌前病变和胃癌中的表达

The Expressions of p53、p21^(WAF1) and p16 in the Gastric Precancerous Lesions and the Cancer

目的 研究 p5 3、p2 1WAF1、p16在胃癌前病及胃癌发生发展中的作用 ,探讨他们之间的相互关系。方法 采用SP免疫组化法检测慢性萎缩性胃炎 6 5例、肠化 93例、胃上皮不典型增生94例、胃癌 6 0例中三者的表达。结果 随着病变的发展三者均有较明显失活 (P <0 .0 5 )。结论 p5 3、p2 1WAF1及 p16的失活对于胃癌的发生有重要作用 ,p5 3和 p2 1WAF1的失活有协同性属于癌症发生的相对晚期事件 ,p16的失活发生于病变早期。

Objective To investigate the expressions of p53?p21 WAF1 and p16 and their interrelationship in the gastric carcinogenesis.Methods The expressions p53?p21 WAF1 and p16 were detected by means of SP immunohistochemical staining in the 65 cases of chronic atrophy gastritis, 93 cases of intestinal metaplasia, 94 cases of gastric epithelia dysplasis, 60 cases of gastric carcinoma.Results With the development of the lesion,they were abnormal gradually( P <0.05),especially in the moderate, severe dysplasia and the cancer( P<0.01 ),furthermore the variation of p21 WAF1 was increased with the mutant of p53 significantly ( P<0.05 ). Conclusion The variations of p53?p21 WAF1 and p16 play great roles in the gastric cancinogenesis.the mutations of p53?p21 WAF1 belong to the later events, otherwise p16 is the earlier one.