血清透明质酸与大肠癌的关系及临床意义

The Clinical Significance of Hyaluronic Acid in Patients with Colorectal Cancer

目的 研究血清透明质酸 (HA )与大肠癌的关系及临床意义。方法 病例分为大肠癌组 ( 4 7例 )、良性肿瘤组 ( 31例 )和非肿瘤对照组 ( 4 0例 ) ,应用放射免疫法分别测定其血清HA水平 ,并分析临床分期、根治手术、淋巴结转移等与HA水平变化的关系。结果 大肠癌患者血清HA水平 ( 10 8.5 μg/L± 31.2 μg/L )明显高于良性肿瘤组和非肿瘤对照组 ,P <0 .0 1,且与肿瘤Dukes分期、淋巴结转移有密切关系 ;手术切除后HA水平则明显降低 ( 4 5 .3μg/L± 12 .1μg/L) ,P <0 .0 1。结论 在一定程度上血清HA水平反映了大肠癌生物学行为 ,并对大肠癌的诊断、疗效判断和综合治疗方案的制定具有指导意义。

Objective To investigate the relation between the biological character and blood hyaluronic acid(HA) of colorectal cancer and clinical significances of HA.Methods The patients were divided into three groups,namely,colorectal cancer group(47 cases),benign tumour group(31 cases) and non-neoplasm control group(40 cases),the radioimmunoanalysis was used to detect the content of HA,the changes of HA were studied in different Dukes stages,operation and lymphnodes metastasis as well.Results The contents of HA in colorectal cancer group(108.5 μg/L±31.2 μg/L) were highest among the three groups(P<0.01),on the other hand,they had the close relation to the Dukes stages and lymphodes metastasis.After operation,the HA contents decreased obviously( 45.3 μg/L±12.1 μg/L),P<0.01.Conclusion To some degree,the content of HA reflected the biolobical behaviour of colorectal cancer,and has the guiding significances to the diagnosis,the judgement of curative effect of operation and the drafting of synthetic program of treatment in the patients with colorectal cancer.