CT导引肿瘤内注药联合支气管动脉化疗治疗晚期中心型肺癌的研究

Treatment of later central type of lung carcinoma guided by CT and intratumor carboplatin injection plus bronchial artery chemotherapy

目的 :研究CT导引下卡铂瘤内注射 (ICI)联合支气管动脉化疗 (BAI)治疗晚期中心型肺癌的可行性及临床价值。方法 :治疗组 30例Ⅲ、Ⅳ期中心型肺癌 ,CT导引ICI注入卡铂联合BAI,对照组 46例Ⅲ、Ⅳ期中心型肺癌单独行BAI。通过CT、组织学、生活质量及生存期等指标观察疗效。结果 :治疗组近期疗效有效率 73% ,对照组 5 4% ,治疗组明显高于对照组 ,差异显著 (P <0 .0 5 )。结论 :CT导引下卡铂ICI联合BAI,对晚期中心型肺癌有显著疗效。

Objective:To investigate the feasibility and clinical efficacy of intratumor carboplatin injection (ICI) plus bronchial artery infusion (BAI),guided by CT in treating later central type of lung carcinoma .Methods: 30 patients with stage Ⅲand Ⅳ central type carcinoma of lung were treated as up ideas,while 46 patients with same stages were treated merely by BAI as control group.Therapeutic effect was evaluated accorging to the improvement of the following variables:CT pathohistologic picture of the biopsy specimen,life quality and survival period after treatment.Results:The responsive rate in the treatment group was 73%,while that in the control group was 50%.They were significant different(P<0.05).The treatment group was higher than the control group.Conclusions:Aspiration biopsy guided of CT and ICI plus BAI had notable effect on therapeutic of later central type of lung carcinoma.