血清TNF-α变化在小儿全身炎症反应综合征中的作用

Detection of serum tumor necrosis factor α and its clinical significance in children with systemic inflammatory response syndrome caused by infectous disease

目的 探讨肿瘤坏死因子 (TNF -α)在全身炎症反应综合征 (SIRS)中的作用。方法 用酶联免疫吸附法 (ELISA)检测 46例感染性疾病患儿 (其中SIRS 2 6例、非SIRS 2 0例 )及 2 0例健康体检儿的血清TNF -α含量。结果 SIRS组患儿血清TNF -α含量明显高于非SIRS组与正常对照组 (P <0 .0 1) ,且血清TNF -α含量随符合SIRS诊断标准数目的增多而增高。结论 TNF -α是SIRS中的主要炎性介质 。

Objectives To explore the mechanism of tumor necrosis factor α(TNF-α) of systemic inflammatory response syndrome (SIRS).Methods The levels of serum TNF-α of 46 cases with infectous disease (26 cases were SIRS, 20 cases were non-SIRS) were detected by enzymerlinked immunosorbent essay (ELISA)and were compared with those of 20 normal children.Results The levels of the cases with SIRS significantly higher than those in the cases without SIRS and those in normal contral group (P< 0.01). The more SIRS standards the patient conformed to,the higher the serum level of the TNF-α was. Conclusions TNF-α is the main inflammatory intermediataries of SIRS.It acts the key demage of organs.