决闭胶囊抗实验性前列腺增生的研究

Effect of Juebi Capsule on Experimental Prostatic Hyperplasia

目的 :探讨决闭胶囊对实验性前列腺增生的治疗作用。方法 :采用睾丸素所致小鼠和去势所致大鼠的前列腺增生模型及去甲肾上腺素诱发免离体膀胱三角肌收缩抑制 ,观察决闭胶囊的抗前列腺增生作用。结果 :小鼠以每日 10g/kg和 2 0 g/kg决闭胶囊灌胃 ,连续 10d ,大鼠每日以 1g/kg和 2 g/kg决闭胶囊灌胃 ,连续 3周 ,均可显著性地抑制丙酸睾丸素引起的小鼠和大鼠前列腺性增生 ,表现为前列腺湿重减轻 ,前列腺DNA含量明显降低 ,血清酸性磷酸酶活性明显降低。0 .2 5 % ,0 .5 0 %及 0 .75 %决闭胶囊水混悬液尚可抑制去甲肾上腺素诱发的免离体膀胱三角肌收缩作用 ,抑制率分别为2 9 .17% ,4 1.72 % ,62 .2 9%。结论 :决闭胶囊具有显著抑制前列腺增生的作用 ,并且具有对抗α受体激动剂诱发的膀胱三角肌收缩的作用。

Objective: To observe the effect of Juebi capsule (JBC) on experimental prostatic hyperplasia. Methods: Experimental prostatic hyperplasia was induced by castration testicular nourmone in the mice and rats respectively and the isolated bladder trigone muscle of the rabbit was used for contraction inhibition. Results: For mice, JBC 10 20g/kg was administered intragastrically for 10 days; for rats, JBC 1 2g/kg was taken for 3 weeks. The results showed that JBC can significantly inhibite prostatic hyperplasia and decrease wet weight of the gland, DNA content and the activity of serum acid phosphatase. Otherwise, 0.25%, 0.50% and 0.75% water suspension of JBC also can inhibite the contraction induced by norepinephrine in isolated bladder trigone muscle of the rabbit. The inhibition rates were 29.17%, 41.72% and 62.29%.Conclusion: JBC can significantly inhibit experimental prostatic hyperplasia and decrease contraction of bladder trigone muscle induced by α adrenoceptor agonist.