p16蛋白在膀胱癌和腺性膀胱炎中的表达

Expression of p16 gene in carcinoma of bladder and cystitis glandularis

目的 探讨p16蛋白在膀胱癌和腺性膀胱炎中的表达及意义。 方法 用p16蛋白单克隆抗体对 49例膀胱癌、10例腺性膀胱炎石腊切片进行免疫组化 (S -P法 )染色。 结果 49例膀胱癌中 ,p16蛋白阳性表达率为 38.78% ,阳性表达与膀胱癌病理组织学分型、分化程度、复发与否无明显相关性 ,但与浸润深度有相关性 ,无浸润组阳性率为 5 3 .5 7% ,有浸润组阳性率为 19.0 5 % (P <0 .0 5 )。 10例腺性膀胱炎 p16蛋白均未表达。 结论 检测 p16蛋白对于了解膀胱癌生物学行为具有重要意义。

Objective To investigate expression of p16 gene in carcinoma of bladder and cystitis glandularis. Methods p16 gene expressions were analyzed in 49 patients with carcinoma of bladder and 10 patients with cystitis glandularis by immunohistochemical method. Results Positive expression rate of p16 protein in 49 patients with carcinoma of bladder was 38.78%. Positive expression had no relationship with histological type, differential degree, recurrence of carcinoma of bladder, and was correlative with infiltrative degree. The positive rate was 53.57% in not infiltrative,19.05% in infiltrative (P<0.05) and p16 protein weren't expressed in 10 patients with cystitis glandularis. Conclusion Detection of p16 gene may be helpful in understanding biological features of carcinoma of bladder.