肝硬化患者血浆前列环素与门脉高压的关系

The relationship between portal hypertension and plasma prostaglandin Ⅰ_2 in patients with cirrhosis

目的:了解肝硬化患者血浆前列环素的变化及其临床意义。方法:应用特异性放射免疫分析法测定46例肝硬化患者及30例正常对照者血浆前列环素水平;B 超测定门静脉直径。结果:46例肝硬化患者前列环素水平(138.28±60.74pg/ml)明显高于对照组(89.6±22.6pg/ml,P<0.05)。肝硬化患者中,Child-Pugh A、B、C各级间比较均无明显差异(P>0.05)。43例肝硬化患者前列环素水平与门静脉直径呈明显正相关(r=0.324,P<0.05)。结论:肝硬化患者血浆前列环素明显升高,其与门脉高压高血流动力学的产生有一定关系。

Objective:To evaluate the changes of plasma prostaglandin Ⅰ_2 (PG Ⅰ_2) and its patho-physiological significance in patients with liver cirrhosis. Methods: Plasma prostaglandin Ⅰ_2 concentrationwas measured hy radioimmunoassay in 46 patients with liver cirrhosis (child-pugh A in 8,child-pugh B in24, child-pugh C in 14) and 30 healthy controls. Ultrasonography was used to detect the portal vein diam-eter in 43 cirrhotic patients.Results: Plasma PG Ⅰ_2 level was signficantly increased in patients with cir-rhosis compared to healthy controls (138.28±60.74pg/ml VS. 89.6±22.6pg/ml, mean±SE, P<0.05).Morever, a close positive correlation existed between the level of plasma PG Ⅰ_2 and portal vein diameter(r = 0.324, P<0.05). Conclusion: The level of plasma PG Ⅰ_2 was shown to be increased in cirrhotic pa-tients,supporting that its synthesis by blood vessels of systemic circulation is enhanced and the elevatedPG Ⅰ_2 contribute to the hyperhemodynamics in portal hypertension.