摘要
目的 探讨阿尔茨海默病患者血浆脱氢表雄酮 (DHEA)水平的变化。 方法 采用放射免疫法测定 48例阿尔茨海默病患者血浆DHEA的水平 ,并与 44例正常老年人 (对照组 )进行比较。 结果 阿尔茨海默病患者血浆DHEA的平均水平是 ( 3 342± 1 438)ng·ml-1,而对照组为 ( 6 6 6 4± 1 6 2 4)ng·ml-1,2组间比较有显著性差异 (P <0 0 5 )。 结论 阿尔茨海默病的发生可能与其血浆DHEA水平的下降有关 ,DHEA可作为阿尔茨海默病的一项诊断指标。
Objective To investigate the serum dehydroepiandrosterone level in Alzheimers disease. Methods The concentration of dehydroepiandrosterone was detected using radioimmunoassay in 48 AD patients and 44 healthy control subjects. Results The concentration of dehydroepiandrosterone in AD was(3 342±1 438)ng·ml -1 ,while it was(6 664±1 624)ng·ml -1 in normal subjects.There was significant difference between the two groups. Conclusions Our results indicated that there might be correlation between AD and the decrease of dehydroepiandrosterone.DHEA may be a clinical marker in the diagnosis of AD.
出处
《实用老年医学》
CAS
2001年第5期241-242,共2页
Practical Geriatrics
