前列腺素E_1与硝酸甘油治疗老年冠心病疗效对比

Efficacy comparision of prostaglandin E_1 and nitroglycerin in senile coronary heart disease

目的 观察前列腺素E1(PGE1)治疗老年冠心病心绞痛疗效。 方法 将 135例老年冠心病心绞痛患者随机分为 2组。PGE1组 (治疗组 ) 6 8例 ,硝酸甘油组 (对照组 ) 6 7例。治疗组应用PGE110 0 μg静滴 ,1d1次 ,7d为1疗程 ;对照组硝酸甘油 10mg静滴 ,1d1次 ,7d为 1疗程 ,对比观察治疗前后心绞痛发作次数、程度、缓解及消失时间 ,心电图ST -T改变 ,超声心动图测左室射血分数 (EF)、左室周径缩短率 (FS)、每搏输出量 (SV) ,血液流变学参数。 结果 缓解心绞痛总有效率治疗组与对照组分别为 88%和 87%。心电图改善总有效率分别为 79%和80 %。心功能测定EF、FS、SV明显改善者治疗组占 72 % ,对照组占 70 %。但血液流变学效应改变 ,治疗组得到明显改善 5 8例 ( 85 % ) ,而对照组仅有 18例 ( 2 7% )略有改善 ,2组差异非常明显 (P <0 0 1)。 结论 PGE1具有强效扩张冠状动脉 ,同时又能改善血液高粘性及高凝状态 ,抑制血小板聚集。可作为一种很有价值的治疗老年冠心病心绞痛新型药物在临床上观察使用。

Objective To observe the effects of prostaglandin E 1(PGE 1)in elderly cases with coronary heart disease(CHD). Methods One hundred and thirty five elderly cases with CHD were randomly divided into a treatment group( n =68,PGE 1 100 μg qd,iv.drop)and a control group( n =67,nitroglycerin 10mg qd,iv.drop) with the treatment duration for 7 days.Angina pectoris,electrocardiogvam(ECG)ST T,ultrasonic cardiography(UCG),ejection fraction(EF),fractional shortening(FS),stroke volume(SV) and blood rheology were compared within the two groups. Results The total effective rate was 88% for PGE 1 group;and 87% for nitroglycerin group.ECG remission rate was 79% for PGE 1 group;and 80% for nitroglycerin group.EF?FS?SV improvement was 72% for PGE 1 group and 70% for nitroglycerin group.In blood rheology,hyperviscosity and hypercoagulation improvement was 85% for PGE 1 group and 27% for nitroglycerin group( P <0.01). Conclusions PGE 1 is considered valuable agent in anti myocardial ischemia,improvement of hyperviscosity and hypercoagulation of blood,inhibition of platelet aggregation,as well as in the treatment of senile coronary heart disease.