缺血性脑卒中患者血浆NO浓度变化的研究

Study on the changes of NO plasma level in patients with ischemic stroke

目的 研究不同类型的缺血性脑卒中患者的血浆一氧化氮 (NO)浓度变化及其临床意义。方法采用硝酸还原酶法测定 2 30例脑梗死患者、10 3例腔隙性脑梗死患者以及 16 9名正常对照者的血浆 NO浓度。结果 脑梗死组血浆 NO浓度与另两组相比显著增高 (均 P<0 .0 0 1) ,而腔隙性脑梗死患者的血浆 NO浓度低于对照组 (P<0 .0 5 )。结论 脑梗死患者急性期血浆 NO浓度可作为缺血损害的一个参考指标 ;而腔隙性脑梗死组

Objective To study the changes of NO plasma levels in patient with ischemic stroke(IS) of different types.Methods Using HNO 3 deoxidize enzyme method, we examined the levels of plasma NO in 230 patients with cerebral infarction, 103 patients with lacular cerebral infarction and 169 normal controls.Results In cerebral infarction group, the level of plasma NO was significant higher than the two other groups ( P <0 001), but the patients with the lacunar cerebral infarction had lower NO level than the controls( P <0 05). Conclusion The level of plasma NO in the patients with cerebral infarction of acute stage might be a reference index for ischemic damage, and the lower level of NO showed the existence of hypertension in lacunar cerebral infarction group.