氯化汞对小鼠肾脏的急性毒性机制探讨

Studies on mechanism of acute renal toxicity of mercury chloride in mice

目的 进一步探讨氯化汞对肾脏的毒性及作用机制。方法 分别测定氯化汞染毒小鼠的血清肌酐 (Cr)和尿素氮 (BUN)、肾脏脂质过氧化物 (LPO)值及肾脏汞、钙、铁、锌、铜等金属浓度和肾脏组织形态的变化。结果 染毒组小鼠上述指标及肾脏组织形态与对照组相比 ,差异均有显著性。 结论 氯化汞具有明显的肾脏毒性 ,诱发脂质过氧化增强及引起钙、铁、锌、铜等微量元素代谢障碍可能是氯化汞引起肾脏损伤的重要因素。

Objectives To study the acute renal toxicity of mercury chloride and its mechanism.Methods Serum levels of creatinine(Cr)and urea nitrogen(BUN),and levels of lipid peroxide(LPO),mercury(Hg),iron(Fe),calcium(Ca),zinc(Zn),copper(Cu),in the kidney of mice exposed to mercury chloride were determined.Also,morphological changes in the kidney were studied.Results There were significant difference in the above mentioned indicators and morphological changes in the kidney between the exposed and control groups.Conclusions Mercury chloride was obviously toxic to the kidney and induce enhancement of lipid peroxidation and metabolic disturbance of trace elements,such as Ca,Fe,Zn and Cu,which could be the important factors leading to renal damage.