摘要
目的 :探讨甲氨蝶呤在小儿白血病治疗中的药代动力学改变。方法 :2 6例急性淋巴性白血病患儿 ,为预防中枢神经系统白血病应用大剂量甲氨蝶呤 3.0g·m-2 ,治疗 3个疗程 ,每疗程进行 6次血药浓度监测。结果 :2 6例患儿于投药后 2 4h血药浓度出现峰值 ,48h回复到投药前水平。结论 :根据所提供的血药浓度水平结合临床 ,可适当缩短给药间期或增加药物剂量。
Objective:To investigate the pharmacokinetics of m ethotrexate(MTX) in the treatment of chidren leukemia.Methods:26 children were received 3.0g·m -2 with MTX in order to against central nervous system leukemia for three courses.Fluorescence Polariza tion Immunoassay(FPIA) was used to monitor the blood concentration of MTX for si x times in each course of treatment.Results:The peaks of blood concentration of MTX appeared at 24h after administration and returned to the beginning level at 48h.Conclusion:The study indicates that proper shortening of intervals bet ween administrations or increasing the dosage may provide more effective treatme nt for children leukemia.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2001年第10期755-757,共3页
Chinese Journal of New Drugs
