泰勒宁胶囊用于镇痛的临床评价

Evaluation the analgesic effect of compound capsule of oxyco done and acetaminophen

目的 :考察泰勒宁胶囊对术后疼痛及癌症疼痛临床镇痛效果和不良反应。方法 :采用多中心随机开放平行对照试验。共完成 10 2例 ,其中治疗组 72例予泰勒宁 ,单次 1粒或每次 1粒 ,tid ,疗程 1d ;对照组 30例予泰诺因 3号片 ,每次 1片 ,tid ,疗程 1d。结果 :泰勒宁对于手术后或晚期癌症引起的中度或中重度急慢性疼痛总有效率可达 10 0 %。服药后泰勒宁组的疼痛强度差 (PID)均高于对照组 ,经统计学处理 ,有显著性差异 (P <0 .0 0 1)。不良反应发生率较低。结论 :泰勒宁为中强度镇痛药 ,对于手术后或晚期癌症引起的中、重度疼痛有良好的镇痛效果。

Objective:To observe the analgesic effect of compo un d capsule of oxycodone and acetaminophen(Tylox ) in treatment of post operat ion pain and cancer pain in comparison with compound tablet of codeine and aceta minophen.Methods:The study was conducted in 102 patients.They were divided to T ylox ( n =72) in a regimen of 1 capsule(or 1 capsule post operation tid)or compound tablet of codeine and acetaminophen( n =30) in a regimen of 1 tablet s tid for 1 day.Results:The effective rate of Tylox  group was 100% with mild ADRs and there was significant difference ( P < 0.001) between active and contro l groups in analgesic effects.Conclusion:Tylox  is effective in treatment of post operation pain and moderate to severe cancer pain.