2-(1-羟基-3-丁炔基)-5-甲基呋喃催化重排合成2-炔丙基-3-甲基-4-羟基-2-环戊烯酮的研究

Synthesis of 4-Hydroxy-3-methyl-2-(2-propynyl)-cyclopent-2-enone by Catalytic Rearrangement of 2-(1-Hydroxy-3-butynyl)-5-methylfuran

由 2 (1 羟基 3 丁炔基 ) 5 甲基呋喃催化重排合成 2 炔丙基 3 甲基 4 羟基 2 环戊烯酮 (炔丙菊醇 ) ,将传统的两步反应简化为一步反应 ,简化了工艺流程 ,缩短了反应时间 ,炔丙菊醇的产率较高 ,达到 75 .0 % ,高于文献报道的最大值 6 8.0 %。确定了反应的最佳反应条件为 :水作反应介质 ,m(催化剂 )∶m(反应物 ) =3∶10 0 ,反应时间 2

4-Hydroxy 3 methyl 2 (2 propynyl) cyclopent 2 enone was prepared from 2 (1 hydroxy 3 butynyl) 5 methylfuran via catalytic rearrangement,and the traditional two step reaction was changed into an one step reaction.As a result,the process was shortened.The optimum teachnological conditions were determined that the reaction was conducted in water, m (catalyst)∶ m (reactant)=3∶100 and the reaction was finished in about 23 h.The yield of 4 hydroxy 3 methyl 2 (2 propynyl) cyclopent 2 enone was 75%,which was higher than the maximum value 68.0% reported in literature.