摘要
动物照射前后不同时间给予新型抗放药E838腹腔注射 ,观察其死亡率和死亡动物活存时间 ,并在用药后不同时间检测其外周血白细胞数、骨髓有核细胞数、骨髓粒系祖细胞集落形成单位CFU -GM和造血干细胞CFU -S数 ,研究了E838对放射损伤小鼠存活及造血功能的影响。结果表明 ,E838预防用药能够明显提高损伤动物的 30d存活率及平均活存时间 ,对造血功能的研究结果也表明 ,E838预防用药能够减少损伤后外周血白细胞数、骨髓有核细胞数、骨髓粒 -单系祖细胞数及造血干细胞CFU -S数的下降幅度。显示出E838对放射损伤具有确切的预防效果 。
To study the effects of radioprotectant-E838 on irradiated mice. Irradiated mice were injected intraperitoneally with E838 before and after irradiation. Then, the survival rate and the average living days of dead animals were calculated Meanwhile the peripheral blood WBC , bone marrow nucleate cells,CFU-GM and CFU-S were analysed. When used before irradiation, E838 could significantly increase the suvival rate and the average survival days of dead animals, and reduce the damage of the hematopoietic system. The results show that E838 has a good preventing effect on radiation injury.
出处
《辐射研究与辐射工艺学报》
CAS
CSCD
北大核心
2001年第4期279-282,共4页
Journal of Radiation Research and Radiation Processing
基金
总后卫生部科研基金资助
