螺环倍半萜(±)-α-花柏烯和(±)-β-花柏烯的全合成

Total Synthesis of (±)-α-Chamigrene and (±)-β-Chamigrene

以萜品油烯 ( terpinolene)与 2 ,4 -二氧代戊酸甲酯的 de Mayo反应得到加成产物为起始原料 ,经反 aldol重排 ,再环合成具有螺 [5 ,5 ]十一烷结构的基本碳骨架 ,通过官能团的化学修饰 ,完成了 (± ) -α-花柏烯和 (± )

Chamigrene and (±) β Chamigrene were synthesized via the de Mayo reaction of terpinolene and methyl 2,4 dioxopentanoate to build up the basic skeleton of chamigrene, which was converted into title products after embellishing the functional groups.