摘要
目的:建立盐酸贝凡洛尔片溶出度测定法,并纳入药品标准。方法:选用中国药典2000年版溶出度测定法第二法,紫外分光光度法检测,波长为277nm。结果:在20～80μg/ml范围内,浓度与吸收度呈良好的线性关系(r=0.9999),平均回收率为100.3％,RSD为0.8％(n=6),每片溶出量应为标示量的75％以上。结论:本法适合于盐酸贝凡洛尔片的溶出度测定。
Objective: To develop a method of dissolution test for bevantolol hydrochloride tablets. Methods : Dissolution method I in the Chinese pharmacopoeia 2000 was used and UV spectrophotometry was adopted for the determination at 277 nm. Results:The average recovery was 100. 3% (n = 6,RSD =0. 8%) ,it had good linearity in the concentration range of 20-80μg/ml(r = 0. 9999) ,the percentage of dissolution of bevantolol hydrochloride tablets in 20 min were more than 75%. Conclusion :This method could be applied to the determination of dissolution of bevantolol hydrochloride tablets.
出处
《中国药品标准》
CAS
2001年第4期60-62,共3页
Drug Standards of China
