硝普纳对重症急性胰腺炎家兔血浆NO、SOD影响的研究

AN EXPERIMENTAL STUDY ON THE EFFECT OF SNP ON THE SODIN PLASMA OF ANP OF RABBITS

目的 :为了进一步探讨重症急性胰腺炎 (ANP)的发病机制及硝普纳的治疗作用。方法 :采用胰管内注射 5 %的牛磺胆酸钠的方法建成家兔ANP模型 ,动态观察血浆NO、SOD的变化、相应胰腺组织学改变及硝普钠对其的影响。结果 :ANP模型组血浆NO、SOD明显下降 (p <0 .0 5 ) ,而治疗组血浆NO、SOD明显高于非治疗组 (p <0 .0 5 ) ,胰腺组织学改变明显减轻。提示 :ANP早期即出现胰腺微循环障碍 ,胰腺组织缺血、缺氧、氧自由基的生成增加参与了ANP的病理过程 ,硝普钠的早期应用可以改善胰腺血循环障碍 ,减少氧自由基的生成 ,从而减轻病损改善预后。硝普钠对重症急性胰腺炎有潜在的治疗价值。

Objective :To observe the cause of ANP and the effect of SNP treatment on it.Method:Using ANP model in rabbits, we dynamically observed the levels of no?sod in plasma at points as well as the effect of SNP(a sort of No donordrugs)on them.Meanw we also observed the pathological alterations of pancreatic tissues. Results:The results showed that the level ofno?sod in plasma were lower(p<0.05)in model group;While the level of no?sod in plasma in SNP treatment group were higher(p<0.05),meanwhile the pathological alterations of pancreatic tissues obviously became less serious comparing with the model group. Conclusions:The results suggested that the pancreatic mirocirculation was obstacled at the early stage of the ANP and the pancreatic tissues were deficient in blood and oxygen. This could result in the increase of OFR which caused the damage of pancreatic tissmes.Our study also indicate that applying SNP earlier can improve pancreatic microcirculation,lessen the OFR,reduce the damage of pancreatic tissues in experiment. Therefore,It provided a new method for treatment of clinic ANP.