摘要
目的 :探讨利用肝细胞去唾液酸糖蛋白受体 (ASG受体 )介导的LAC HSA SPIO对比剂检测肝癌的可能性。方法 :建立二乙基亚硝胺诱导的大鼠肝癌模型 ( 8例 ) ,获平扫及注射LAC HSA SPIO ( 1.2mgFe/10 0g体重 )后大鼠肝脏双回波SE像 ( 2 0 0 0 /30～ 80 ) ,测定肝实质强化率 (PCE)和肝癌灶信号对比度 /噪声比 (CNR)。结果 :①注药后在T2 WI肝实质PCE为 71.8%± 16.3% ,癌结节为 10 .2 %± 4.8% (P <0 .0 1) ;②增强后PD WI上瘤结节CNR由平扫时 1.6± 0 .3上升至 8.2± 4.6(P <0 .0 1) ,T2 WI癌结节CNR由 4.7± 3.1上升至 8.9± 4.0 ( 0 .0 1<P <0 .0 5 )。结论 :LAC HSA SPIO增强MRI对发现小肝癌灶有重要价值。
Objective:To explore feasibility of LAC HSA SPIO as a contrast targeted to asialoglycoprotein receptor to detect micro hepatocellular carcinoma(HCC) in rats.Methods:Rat model with HCCs was established by chemical induction of diethylnitrosamine(n=8).Both proton density weighted images(PD WI)and T 2 weighted images(T 2 WI)were obtained before and 2h after intravenous injection of LAc HSA SPIO(1.2mgFe per 100 gram body weight).And percent contrast enhancement (PCE) of hepatic parenchyma and CNR of HCC to liver were measured subsequently.Results:After administration of LAC HSA SPIO, observed were the followings: ①PCE of hepatic parenchyma on T 2WI with the averaged 71.8%±16.3% was significantly lower than that of HCC (-10.2%±4.8%, P < 0.01); ②CNR of HCC to liver increased from 1.6±0.3 to 8.2±4.6( P <0.01) on PD WI, while 4.7±3.1 to 8.9±4.0(0.001< P <0.01) on T 2WI.Conclusion:LAC HSA SPIO enhanced MRI may provide a promising approach to assess the function of ASG receptor. And also it is valuable to improve detection of HCCs in rats.
出处
《放射学实践》
2001年第6期378-380,共3页
Radiologic Practice
