缺碘者吸烟与女性性激素代谢关系及其影响

Relationship and Influence Between Iodine Deficiency with Smoke Inhalation and Women's Sex Hormone Metabolism

目的 探索缺碘者吸烟女性性激素代谢及影响。方法 通过尿碘和甲状腺体积 (超声法 )及吸烟史 (以血铅为指示 ) ,将碘缺乏病流行区生育期女性分为缺碘吸烟组 (ID +SI)及对照组 ,于上次月经第 12～ 15天空腹抽取静脉血测定Pb和Se(原子吸收光谱法 ) ,放免法测定雌二醇 (E2 )。结果 缺碘和铅高负荷与E2 含量不足呈密切正相关 (r =0 85 0 P <0 0 1) ,与Se缺乏和LPO含量增多有密切的负相关和正相关 (r分别为 0 784和 - 0 845 P均 <0 0 1)。结论 缺碘者吸烟会加重铅负荷 。

Objective To approach the effects of iodine deficiency and smoke inhalation on women's sex hormone metabolism.Methods The pregnancy women in the epidemic area of iodine eficiency disease were divided into iodine deficiency and smoke inhalation group(ID+SI) and control group by urinary iodine,thyroid's volume(ultrasonic method) and the history of smoking(using blood lead as index).The vein blood tests were taken on an empty stomach on day 12-25 after the last menstruation,Pb and Se were determined(atomic absorption photometer) and estradiol(E 2) was determined by radioimmunity method.Results Iodine deficiency and high lead load had closed positive correlation with inadequate content of E 2( r=0 850,P<0 01) ,and closed negative and positive correlation with selenium deficiency and LPO increasing( r =0 784 and -0 845 respectively, P av <0 01).Conclusion Iodine deficiency with smoke inhalation can aggravate lead load,iodine deficiency and lead load increasing had co-effect on inhibition of women's sex hormone metabolism.