pS2、PSA的表达与乳腺癌神经内分泌分化的关系

Relationship Between pS2 Protein and Prostate-specific Antigen Expression and Neuroendocrine Differentiation of Breast Carcinoma

目的 :探讨雌激素调节蛋白 (p S2 )、前列腺特异抗原 (PSA)的表达与乳腺癌神经内分泌细胞 (NE细胞 )分化的关系。方法 :应用 LSAB免疫组化法检测铬粒素、p S2及 PSA在 1 30例乳腺癌患者中的表达。结果 :1 NE细胞阳性乳腺癌 p S2阳性表达率为 72 .2 % ,明显高于 NE细胞阴性者45.0 % (P<0 .0 5)。 2浸润性导管癌及浸润性小叶癌 PSA阳性率为 1 8.9% ,明显低于其它类型癌37.5% (P<0 .0 5)。3NE细胞阳性乳腺癌 PSA阳性率为 55.0 % ,明显高于 NE细胞阴性者 1 6 .4%(P<0 .0 5)。结论 :提示伴有神经内分泌分化的乳腺癌恶性度较低 。

Objective:To study the relationship between the expression of pS2 protein, prostate specific antigen(PSA) and breast carcinoma with neuroendocrine (NE) cells differentiation. Methods:Using LSAB immuno histochemical method, chromogranin, pS2 protein and PSA expression of 130 cases of breast cancer were detected. Results:①pS2 protein positive rate in breast carcinoma with neuroendocrine cells was 72.2%, significantly higher than that of breast carcinoma without neuroendocrine cells( P <0.05); ②PSA positive rate in infiltrating ductal carcinoma and invasive lobular carcinoma was 18.9%, significantly lower than that of other types of carcinoma ( P <0.05).③ The positive rate of PSA in breast carcinoma with neuroendocrine cells was 55.0%, were significantly higher than that of breast carcinoma without neuroendocrine cells( P <0.05).Conclusion:The suggesting that the breast carcinoma with neuroendocrine differentiation is a lower grade malignant tumor with a better prognosis.