摘要
目的 :探讨止痛胶囊对佐剂性关节炎大鼠模型 (AA大鼠 )白细胞介素 1(IL -1)、肿瘤坏死因子 (TNF)、前列腺素E2 (PGE2 )活性的影响。方法 :建立佐剂性关节炎 (adjuvantarthritis ,AA)大鼠模型。用双抗体夹心ELISA法测AA大鼠IL -1活性。用放射免疫法检测TNF和PGE2 活性。结果 :止痛胶囊能显著降低AA大鼠血清中IL -1、TNF和PGE2 的含量。结论 :IL -1、TNF、PGE2 在类风湿关节炎 (RA)发病机理中占重要地位 ;止痛胶囊能控制AA大鼠血清中IL -1、TNF、PGE2 等炎症介质的活性 。
Objective:To explore the active effects of compound ZHITONG JIAONANG on IL-1 TNF and PGE 2 in the rat model of adjuvant arthritis(AA).Methods:The AA rat model was made.Then,the activity of IL-1 of AA rat was determined with the method of ELISA.The activities of TNF and PGE 2 were also determined with the radioimmune method.Results:The Content of IL-1 TNF and PGE 2 in serum of AA rat was significantly reduced by ZHITONG JIAONANG.Conclusion:IL-1 TNF and PGE 2 play an important role in the pathogenesis of rheumatoid arthritis (RA). ZHITONG JIAONANG has the inhibitory effect on the activity of inflammatory mediums and responds well to treating RA.
出处
《江苏临床医学杂志》
2001年第5期372-374,共3页
Journal of Jiangsu Clinical Medicine
基金
江苏省科委立项资助项目(NO .96361 )
