载脂蛋白E基因多态性与Alzheimer病和动脉硬化性脑梗死的关系

Study on the relationship between gene polymorphysm of apolipoprotein E and Alzheimer disease, atherosclerotic cerebral infarction

目的 探讨Alzheimer病 (AD)、动脉硬化性脑梗死 (ACI)患者的载脂蛋白E(apolipoproteinE ,ApoE)基因的分布 ,分析它们的相关性。方法 利用聚合酶链式反应 -限制性片段长度多态性 (polymerasechainreaction -restrictionfragmentlengthpolymorphism ,PCR -RFLP)技术对AD患者、动脉硬化性脑梗死患者和相应健康对照的ApoE基因进行分型。结果 AD患者和ACI患者ApoE等位基因ε4明显高于正常人对照组 ,而ε3则低于正常人对照组。结论 ApoE等位基因中 ,ε4可能为AD和ACI的易患因子 。

Objective To study the distribution of Apo E gene in patients with Alzheimer desease and atherosclerotic cerebral infarction, analyse the relationship. Methods Apo E genotyes of patients with Alzheimer desease, atherosclerotic cerebral infarction and age-matched healthy controls were determined by using the polymerphism technique. Results Apo E E ε 4 allele was significantly higher, and ε 3 lower in patients with AD or ACE, in comparison with normal control. Conclusion In Apo E allele,ε4 allele may be a genetic suscetible factor of AD and ACI,ε3 allele may be a protection factor.