恶性肿瘤患者血清TNF-α和IL-6浓度的测定

The Determination of Serum TNF-α and IL-6 Concentratrion in Malignant Tumor Patients

目的 探讨恶性肿瘤患者血清中肿瘤坏死因子 (TNF α)和白细胞介素 6 (IL 6 )浓度的变化及其临床意义。方法 采用ELISA法测定 190例恶性肿瘤患者和 40例健康人血清中TNF α和IL 6浓度。结果 恶性肿瘤患者的TNF α和IL 6浓度均高于健康组 (P <0 .0 1) ,特别是乳腺癌骨转移患者的TNF α浓度是对照组的 10倍 ,而IL 6浓度是对照组的 2 .5倍 ;同种恶性肿瘤患者未手术者TNF α和IL 6浓度水平也均高于术后复发者。结论 血清中TNF α和IL 6浓度可能与恶性肿瘤发生、发展有关。其浓度测定可能作为临床病情观察和监测疗效的辅助手段。

Objective To study the concentration change and clinical significance of tumor necrosis factor(TNF-α) and interleukin-6(IL-6) in the malignant tumor patients.Methods Serum TNF-α and IL-6 concentration in 190 cases of malignant tumor and 40 normal controls were studied by ELISA.Results Serum TNF-α and IL-6 concentration were significatly higher in all malignant tumor patients than in normal controls(P<0.01).The concentration of serum TNF-α in bone transferring patients with breast cancer was 10 times higher than in normal control and the IL-6 was 2.5 times higher.The serum concentration of TNF-α and IL-6 in the non operative patient was higher than in post-operation recurrent patients.Conclusion The concentration of serum TNF-α and IL-6 may associate with development of malignant tumor.The determination of TNF-α and IL-6 concentration in serum could help to observation of the malignant tumor state as an assistant monitor method.