进展期胃癌术后双径路化疗的临床研究

Clinical Studies of between Two-way Chemotherapy for Advanced Gastric Cancer

目的 比较双路化疗与全身化疗治疗进展期胃癌的疗效和毒副反应。方法 6 5例进展期胃癌随机分为 2组 ,其中 30例双路化疗 ,35例全身化疗。结果 双路化疗组 2年 ,3年 ,4年 ,5年生存率明显高于全身化疗组 (P <0 .0 5 ) ,双路化疗组的腹腔复发和(或 )肝脏转移明显少于全身化疗 (P <0 .0 5 ) ,2组的主要毒副反应无差异 (P <0 .0 5 ) ,未见并发症。结论 双路化疗可提高进展期胃癌生存率 ,对防治腹腔复发和 (或 )肝脏转移有明显疗效。

Objective To compare the therapeutic effects and toxicitiy of two way chemotherapy and intravenous chemotherapy on advanced gastric carcinorma.Methods 65 cases of advanced gastric carcinorma were diivided randomly into two groups.30 cases received two way chemotherapy,and the other 35 cases received intravenous chemotherapy.Results 2-year?3-year?4-year?5-year survial rates in two-way chemotherapy were obviously higher than those in intravenous chemotherapy, P <0.05.Peritoneal and (or) liver metastasis in two-way chemotherapy was obviously lower than that of intrasurvial, P <0.05.There was no significant difference in side effects between the two groups.Conclusions Two-way chemotherapy in advanced gastric cancer may improve the survival rate and prevent peritoneal and(or) liver metastasis.