血浆胃动素及血管活性肠肽在腹部手术胃肠动力恢复前后的含量变化

Measurement of Plasma Motilin and Vasoactive Intestinal Peptide Contents in Postabdominal Operation Patients before and after Gastrointestinal Function Recovery

目的 :观察腹部手术胃肠动力与血浆胃动素与血浆VIP含量变化的关系。方法 :用放免法测定5 0例腹部手术在胃肠动力恢复前后血浆Mot及VIP含量的变化。结果 :腹部手术胃肠动力恢复前血浆Mot含量较动力恢复后明显减低 ,而VIP的测定结果与Mot含量变化规律相反。结论 :Mot与VIP均参与了腹部手术后胃肠功能的调节 ,若能找到一种VIP拮抗剂或受体阻滞剂可能是加快腹部胃肠功能恢复的良好手段。

Objective To study the relationship between gastrointestinal function and plasma Motilin(Mot) as well as Vasoactive Intestinal Peptide(VIP) levels after abdominal operations. Methods Plasma Mot and VIP levels were measured with RIA in 50 postabdominal operation patients before and after gastrointestinal function recovery. Results Plasma Mot levels in patients before gastrointestinal function recovery were significantly lower than those after recovery but changes in plasma VIP levels were just reversed. Conclusion Mot and VIP might play important role in regulation of gastrointestinal function after operation. Future discovery of VIP antagonist or receptor blockader might provide good means to hasten gastrointestinal functional recovery.