多种方法检测的Dukes B期大肠癌淋巴结微转移与病人预后相关

MULTIDETECTION IN REGIONAL LYMPH NODE MICROMETASTASIS FROM DUCKS B STAGE COLORECTAL CARCINOMA AND ITS IMPACT ON PROGNOSIS

目的 :探讨Dukes’B期大肠癌患者淋巴结微转移的检测方法及与预后的关系。方法 :免疫组化和PCR方法同时检测石蜡切片大肠癌淋巴结微转移。结果 :术后 5年以上无复发或转移组 2 2例微转移检测阳性率为0～ 2 5 % ,术后 5年以内复发或转移组 2 4例检测阳性率为 2 2 %～ 6 7% ,两组比较具有显著性差异。结论 :Dukes’B期大肠癌淋巴结微转移阳性者预后不良 ,术后应予以更加积极的治疗。

Objective:To evaluate respectively the detective method of lymph node micrometastasis and the association between the micrometastasis and prognosis in patients with Dukes' B colorectal cancer.Methods:Both immunohistochemistry and Polymerase-chain reaction were used in detecting micrometastasis in paraffin slides selected from colorectal cancer and its regional lymph nodes.Results:Patients were divided into two groups:Group 1 were 22 patients who had no reccurrence or metastasis more than 5 years; group 2 were 24 patients who had recurrence or any other clinical metastasis within 5 years. The positive rate of micrometastasis in each group was 0～25% and 22～67%,which showed a significant deference.Conclusions:Our study shows that patients with Dukes' B colorectal cancer who have regional lymph node micrometastasis have poor prognosis,and should be treated more aggressively.Multidetection is more reliable.