Ⅱ,Ⅲ期乳腺癌术后同步放化疗可行性研究

FEASIBILITY STUDY SIMULTANEOUS ADJUVANT RADIOTHERAPY AND CHEMOTHERAPY OF FOR Ⅱ AND Ⅲ STAGE BREAST CANCER AFTER MASTECTOMY

目的 :通过对比观察Ⅱ ,Ⅲ期乳腺癌术后放化疗同步与非同步两组患者治疗过程的近期不良反应及耐受性 ,探讨乳腺癌术后同步放化疗的可行性。方法 :乳腺癌术后患者分为放化疗同步组 (36例 )和放化疗非同步组 (31例 ) ,观察治疗过程中不良反应。结果 :同步组和非同步组患者均能完成术后辅助性放化疗 ,Ⅲ度以上白细胞减少发生率以及Ⅲ度放射性皮炎同步组较非同步组多 ,但两组间比较无显著性差异 (P >0 .0 5 )。恶心呕吐、肝肾功能损害发生率以及心电图异常发生率两组间比较无显著性差异 (P >0 .0 5 )。结论

Objective:To evaluate the feasibility of simultaneous adjuvant radiotherapy and chemotherapy for stage Ⅱ nad stage Ⅲ breast cancer after mastectomy.Methods:Thirty-six patients with breast cancer after mastectomy were treated with simultaneous adjuvant radiotherapy and chemotherapy (simultaneous group),while 31 equivalent cases received non-simultaneous adjuvant therapy (non-simultaneous group).Results:The two groups finished the planned adjuvant therapy.The incidences of radiation dermatitis and leukopenia were less in simultaneous group than in non-simultaneous group.There were no differences in radiation dermatitis,leukopenia,nausea,vomiting,liver-renal toxicity and EKG abnormality between the two groups.Conclusions:Simultaneous adjuvant radiotherapy and chemotherapy for stage Ⅱ and stage Ⅲ breast cancer after mastectomy are feasible.