非络地平对原发性高血压患者心肌保护的影响

EFFECTS OF FELODIPINE ON MYOCARDIAL PRESERVATION OF ESSENTIAL HYPERTENSION

目的 :研究原发性高血压患者服用非络地平 ,其心肌缺血改善的情况。方法 :将 47例原发性高血压患者经过 6周的观察期后分为 2组 ,氢氯噻嗪 +非络地平组 (A组 ,n =2 5 ) ,氢氯噻嗪 +安慰剂组 (B组 ,n =2 2 )。接受治疗 12周 ,治疗前后做 12导联心电图 ,测定QT离散度 (QTd)、ST段及T波的变化情况。结果 :经过非络地平和安慰剂治疗 12周后 ,非络地平组QTd明显缩短 (P <0 .0 0 1) ,ST段下降导联数及异常T波导联数均显著减少 (P均 <0 .0 0 1) ,安慰剂组各指标无明显变化。结论 :非络地平能够明显改善原发性高血压病心肌缺血 。

Objective:To study the amelioration of myocardial ischemia of patients with essential hypertension after taking Felodipine.Methods:After 6 weeks' observation,47 patients with essential hypertension were randomly divided into 2 groups: Hydrochlorthiazide(Hyd)+Felodipine(group A,n=25) and Hyd+Placebo(group B,n=22).They were treated for 12 weeks. Before and after the therapy,12 leads electrocardiogram were detected.QT interval dispersion(QTd),ST segment and T wave were tested.Results:After 12 weeks' treatment with Felodipine and Placebo, Felodipine group: QTd was distinctively shortened(( P <0.001),the descendent amplitudes of ST segment were signficantly decreased ( P <0.001),and the number of lead of descendent ST segment was the same as the number of abnormal T wave( P <0.001, respectively).But there were no obvious changes in Placebo group.Conclusions:Felodipine can distinctively ameliorate myocardial ischemia of essential hypertension and protect heart.