支气管哮喘患儿红细胞免疫状态研究

The Study of Red Cell Immune Function in Children With Asthma

目的 探讨支气管哮喘患儿红细胞免疫粘附功能的变化及糖皮质激素对哮喘患儿红细胞免疫粘附功能的影响。方法 采用酵母菌花环法对 42例支气管哮喘患儿 ,2 8例哮喘缓解期患儿及 2 0例健康儿童进行红细胞C3b受体花环率 (RBC -C3breceptorrosetterate,RBC -C3bRR)及红细胞免疫复合物花环率 (RBC -Immuno complexrosseterate,RBC -ICR)检测 ,同时检测 2 8例哮喘患儿缓解期应用激素吸入治疗 1月及 6月后的RBC -C3bRR及RBC -ICR。结果 哮喘发作组RBC -C3bRR较缓解组和对照组均明显下降 (P <0 0 5 ,P <0 0 1)。RBC -ICR较对照组升高 (P <0 0 5 )。哮喘患儿缓解期应用激素吸入治疗 1月后 ,RBC -C3bRR较未用药组高 ,差异有显著意义 (P <0 0 5 )。两组RBC -ICR差异无显著性 (P >0 0 5 )。激素治疗 6月后 ,RBC -C3bRR较未用药组明显升高 ,差异有高度显著性 (P <0 0 1)。两组RBC -ICR差异无显著意义 (P >0 0 5 )。结论 支气管哮喘患儿红细胞免疫粘附功能下降。

Objective To explore the change of the red blood cell(RBC) immunoadhensive function in children with asthma and the effect of glucocorticoid on RBC immunoadhensive function.Methods The rosette rate of RBC-C3b receptor(RBC-C3bRR) and rosette rate of RBC-Immunocomplex(RBC-ICR) were measured by using yeast rosette method in 42 children with asthma,20 healthy children(control group),and 28 asthmatic children in remission period were measured also by the same methods after one month and six months of glucocorticoid inhalation therapy.Results The levels of RBC-C3bRR were lower in asthma group than that in remission group and control group(P<0 05,P<0 01,respectively);the levels of RBC-ICR were higher in asthma group than in control group.After one and six months of glucocorticoid inhalation therapy in remission group,the levels of RBC-C3bRR were higher significantly than untreated group(P<0 05,P<0 01,respectively).But the levels of RBC-ICR had no significant difference between both treated groups with glucocorticoid after either one month or six months and untreated group(P>0 05).Conclusions RBC immunoadhensive function has shown significant decrease in asthmatic children;and it may be improved by using glucocorticoid inhalation therapy in asthmatic children at remission period.