摘要
目的 探讨进展期胃癌患者脾脏的免疫状态。方法 检测正常人及进展期胃癌患者共 35例脾静脉血和外周静脉血进行T细胞亚群、自然杀伤细胞 (NK细胞 )活性、循环免疫复合物测定。结果 ( 1)与正常人外周血淋巴细胞 (PBL)相比 ,进展期胃癌患者的PBL、脾静脉血淋巴细胞 (SVL)的NK细胞活性及CD+ 3 、CD+ 4细胞降低 ,CD+ 8细胞增多 ,使CD+ 4/CD+ 8比值下降。 ( 2 )从进展期胃癌患者PBL .SVL比较结果可见 ,后者NK细胞活性、CD+ 4/CD+ 8细胞比值明显低于PBL。 ( 3)进展期胃癌患者SVL的循环免疫复合物 (CIC)水平高于其PBL ,也高于正常人PBL。结论 进展期胃癌患者脾脏不但未能起正性免疫作用 ,且逐步转向负性免疫状态。
Objective In order to study the spleen immune status in patients suffered from progressive gastric cancer.Methods The activity of natural killer cells,T lymphocyte subgroups and circulating immunocomplex (CIC) in peripheral blood (PBL) and splenic venous blood (SVL) of 20 cases with progressive gastric cancer were detected.Results The results showed that (1) in comparison with normal PBL of healthy persons,these patients showed a lower NK cell activity,depressed CD + 3 and CD + 4 cell count and increased CD + 8 cell count,resulting in a decrease of CD + 4/CD + 8 ratio.(2)CIC in SVL was not only higher than the normal PBL,but also higher than that in PBL of the same case.Conclusion The authors concluded that the advanced gastric cancer may weaken the patients whole immunity.The spleen exerts no positive immunologic function in the progression of cancer,but rather a negative one.
出处
《中国肿瘤临床与康复》
2001年第6期40-40,39,共2页
Chinese Journal of Clinical Oncology and Rehabilitation
